Design & Modelling
In order to achieve our goal of rapidly detecting highly specific miRNA, we had to create a novel probe.
Our System
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Binding
Amplification
<script type='text/javascript' src='/2017/modelviewer/bio-pv.min.js'></script><!-- [et_pb_line_break_holder] --><div id="viewerphi29"></div><!-- [et_pb_line_break_holder] --><script type='text/javascript'><!-- [et_pb_line_break_holder] -->var options = {<!-- [et_pb_line_break_holder] --> animateTime: 500,<!-- [et_pb_line_break_holder] --> width: 365,<!-- [et_pb_line_break_holder] --> height: 365,<!-- [et_pb_line_break_holder] --> antialias: true,<!-- [et_pb_line_break_holder] --> quality : 'medium',<!-- [et_pb_line_break_holder] --> background: '#4d79ff'<!-- [et_pb_line_break_holder] -->};<!-- [et_pb_line_break_holder] -->var viewerp = pv.Viewer(document.getElementById('viewerphi29'), options);<!-- [et_pb_line_break_holder] --></script><!-- [et_pb_line_break_holder] --><!-- [et_pb_line_break_holder] --><script type='text/javascript'><!-- [et_pb_line_break_holder] --><!-- [et_pb_line_break_holder] -->function loadMethylTransferase() {<!-- [et_pb_line_break_holder] --> pv.io.fetchPdb('/2017/modelviewer/pdbs/phi29.pdb', function(structure) {<!-- [et_pb_line_break_holder] --> viewerp.cartoon('protein', structure, { color : color.ssSuccession() });<!-- [et_pb_line_break_holder] --> viewerp.centerOn(structure);<!-- [et_pb_line_break_holder] --> viewerp.autoZoom();<!-- [et_pb_line_break_holder] --> viewerp.spin( 3.14 / 16 );<!-- [et_pb_line_break_holder] --> });<!-- [et_pb_line_break_holder] -->}<!-- [et_pb_line_break_holder] -->document.addEventListener('DOMContentLoaded', loadMethylTransferase);<!-- [et_pb_line_break_holder] --></script>
Phi-29 protein model (source)
<div id="viewerRE"></div><!-- [et_pb_line_break_holder] --><script type='text/javascript'><!-- [et_pb_line_break_holder] -->// override the default options with something less restrictive.<!-- [et_pb_line_break_holder] -->var options2 = {<!-- [et_pb_line_break_holder] --> animatedTime: 500,<!-- [et_pb_line_break_holder] --> width: 350,<!-- [et_pb_line_break_holder] --> height: 350,<!-- [et_pb_line_break_holder] --> antialias: true,<!-- [et_pb_line_break_holder] --> quality : 'medium',<!-- [et_pb_line_break_holder] --> animateTime: 500<!-- [et_pb_line_break_holder] -->};<!-- [et_pb_line_break_holder] -->// insert the viewer under the Dom element with id 'gl'.<!-- [et_pb_line_break_holder] -->var viewerr = pv.Viewer(document.getElementById('viewerRE'), options2);<!-- [et_pb_line_break_holder] --></script><!-- [et_pb_line_break_holder] --><!-- [et_pb_line_break_holder] --><script type='text/javascript'><!-- [et_pb_line_break_holder] --><!-- [et_pb_line_break_holder] -->function loadRestrictionEnzyme() {<!-- [et_pb_line_break_holder] --> pv.io.fetchPdb('/2017/modelviewer/pdbs/restrictionenzyme.pdb', function(structure) {<!-- [et_pb_line_break_holder] --> viewerr.cartoon('protein', structure, { color : color.ssSuccession() });<!-- [et_pb_line_break_holder] --> viewerr.centerOn(structure);<!-- [et_pb_line_break_holder] --> viewerr.autoZoom();<!-- [et_pb_line_break_holder] --> viewerr.spin( 3.14 / 16 );<!-- [et_pb_line_break_holder] --> });<!-- [et_pb_line_break_holder] -->}<!-- [et_pb_line_break_holder] --><!-- [et_pb_line_break_holder] -->// Earliest point the WebGL context is available.<!-- [et_pb_line_break_holder] -->document.addEventListener('DOMContentLoaded', loadRestrictionEnzyme);<!-- [et_pb_line_break_holder] --></script>
Fragmentation
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Measurement
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